Overview: Polynucleotides are one of the most exciting advances in aesthetic medicine, helping to rejuvenate skin from within by stimulating collagen, improving hydration, and calming inflammation. In this article, we explore what polynucleotides are, how they work, and which skin concerns they can effectively treat. If you’re looking for natural-looking skin regeneration, this treatment may be the perfect solution.

Have you ever heard of polynucleotides? If not, you’re in for a treat. In the world of aesthetics, polynucleotides are quickly becoming one of the most talked-about regenerative skin treatments.

Polynucleotides stimulate the production of two essential proteins: collagen and elastin. These proteins act like scaffolding for the skin, helping it stay firm, smooth, and youthful. By boosting their production, polynucleotides help reduce the appearance of fine lines and wrinkles, giving the skin a fresher, more youthful glow.

Beyond anti-ageing, polynucleotides also improve skin texture, tone, and hydration levels. They even offer anti-inflammatory benefits, helping to calm sensitive or irritated skin while supporting scar repair and overall skin regeneration.

So, what actually are polynucleotides?

Polynucleotides are naturally occurring molecules found in all living organisms, including plants, animals, and humans. They are especially abundant in the nucleus of our cells, which is why they are known as nucleotides.

In aesthetic treatments, polynucleotides are typically derived from natural sources such as trout DNA. Fish DNA closely resembles human DNA, making it an excellent regenerative material for skin treatments. These purified DNA fragments are processed into a gel that can be injected into the skin to promote repair, renewal, and hydration.

At Anti-Ageing Aesthetics, we have introduced PLINEST® Polynucleotides, an advanced injectable treatment that works at a cellular level to repair tissue, stimulate fibroblasts, improve elasticity, boost collagen production, and deeply hydrate the skin.

What concerns will PLINEST® Polynucleotides help with?

1. Fine lines and wrinkles – smoothing lines and improving overall skin quality.
2. Volume loss – restoring subtle fullness for a more youthful appearance.
3. Dull and dry skin – improving hydration and luminosity.
4. Sensitive skin – calming redness and irritation.
5. Acne scarring – promoting smoother, more even skin texture.
6. Hyperpigmentation – helping even out skin tone.
7. Enlarged pores – refining and smoothing the skin surface.

What areas can I have the PLINEST® treatment?

One of the standout treatment areas is the under-eye region. PLINEST® has been formulated specifically to target this delicate area, helping to reduce fine lines, puffiness, and the appearance of dark circles.

The treatment is also highly effective for the face, neck, and décolletage, making it ideal if you want to improve skin texture, firmness, and overall radiance.

How many sessions will I need?

While you may notice improvements shortly after your first session, collagen regeneration takes time. For optimal, long-lasting results, we recommend a course of 3–4 treatments spaced 21 days apart.

Summary

Polynucleotides offer a powerful, natural approach to skin rejuvenation by working at a cellular level to repair, hydrate, and regenerate the skin. With benefits ranging from improved texture and hydration to reduced fine lines and inflammation, PLINEST® Polynucleotides are an excellent option for anyone seeking healthy, youthful-looking skin.